Draw directly with the wacom tablet and pen.
Using programs like Photoshop, Adobe Illustrator, Corel Draw to work in direct sketching.
Draw by hand on paper "the old fashioned way" and then scan the picture.
After dozens of tests ... the best way I found to work in production is:
Create your artwork using pencil on paper. In this way keep the freshness of the creation of hand drawing.
Then take a digital photo of artwork on paper.
And I work with a program of creation of vectors. Tracing and coloring the image.
This is the method that has given me better results so far.
I would like to hear opinions and experiences of other illustrators.
What is the best technique for you to create drawings?